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Active Biotech: Final results from Active Biotech's 10TASQ10 Phase 3 study of tasquinimod presented at the ECC conference

Lund (Sweden) 28 September 2015
- Active Biotech (NASDAQ STOCKHOLM: ACTI) today announces, at the European
Cancer Congress (ECC 2015) held in Vienna 25-29 September, the presentation
of final results from the 10TASQ10 tasquinimod phase 3 trial.

Final results show that tasquinimod treatment resulted in a prolonged
radiographic progression free survival (rPFS), 7.0 vs. 4.4 months (central
assessment) similar to an earlier Phase 2 study. However, the positive effect
on rPFS did not translate into an improved OS (HR 1.097, 95% CI:
0.938-1.282). Tasquinimod safety was in general manageable and similar to
what was observed during the Phase 2 study.

The abstract"A phase 3, randomized, double-blind, placebo-controlled study of
(TASQ) in men with metastatic castrate resistant prostate cancer (mCRPC), M.
Carducci et al"
was selected by the 18th ECCO - 40th ESMO European Cancer Congress Scientific
Committee as a Best Abstract presentation in a Presidential Session (28
September 2015 at 2:35 pm CEST).

About tasquinimod

Tasquinimod is a novel oral immunotherapy that targets the tumor
microenvironment by binding to S100A9 and modulating regulatory myeloid cell
functions, exerting immunomodulatory, anti-angiogenic and anti-metastatic
properties. The development of tasquinimod principally has been focused on
the treatment of prostate cancer, but early clinical studies in other cancer
indications has been performed.

About the 10TASQ10 trial

The 10TASQ10 trial is a randomized, double-blind, placebo-controlled, global
Phase III clinical trial which evaluated tasquinimod in patients with
metastatic castration resistant prostate cancer (mCRPC) who had not yet
received chemotherapy. The aim of the 10TASQ10 study was to confirm
tasquinimod's efficacy, with radiological Progression Free Survival (rPFS) as
primary endpoint and overall survival (OS) as key secondary endpoint. In
April 2015, top line data was presented which showed that tasquinimod reduced
the risk of radiographic cancer progression or death compared to placebo
(rPFS, HR=0.69, CI 95%: 0.60 - 0.80) in patients with metastatic castration
resistant prostate cancer (mCRPC) who have not received chemotherapy, but did
not extend overall survival (OS, HR=1.09, CI 95%: 0.94 - 1.28). The efficacy
results did not support positive benefit risk balance in this patient

For further information, please contact:

Tomas Leanderson, President&CEO
Tel +46 46 19 20 95

Hans Kolam, CFO
Tel +46 46 19 20 44

Active Biotech AB
(publ) (Nasdaq Stockholm: ACTI) is a biotechnology company with focus on
neurodegenerative/inflammatory diseases and cancer. Laquinimod, an orally
administered small molecule with unique immunomodulatory properties, is in
pivotal phase III development for the treatment of relapsing remitting
multiple sclerosis. Also, laquinimod is in phase II development for the
treatment of primary progressive multiple sclerosis and Huntington's disease.
Furthermore, commercial activities are ongoing for the projects ISI, ANYARA
and paquinimod. Please visitwww.activebiotech.comfor more information.

Active Biotech AB (Corp. Reg. No. 556223-9227)
Box 724, SE-220 07 Lund
Tel: +46 46 19 20 00
Fax: +46 46 19 11 00

Active Biotech's Safe Harbor Statement in Accordance with the Swedish
Securities Market Act:
This press release contains certain forward-looking statements. Such
forward-looking statements involve known and unknown risks, uncertainties and
other important factors that could cause the actual results, performance or
achievements of the company, or industry results, to differ materially from
any future results, performance or achievement implied by the forward-looking
statements. The company does not undertake any obligation to update or
publicly release any revisions to forward-looking statements to reflect
events, circumstances or changes in expectations after the date of this press

Active Biotech is obligated to publish the information contained in this press
release in accordance with the Swedish Securities Market Act and/or
the Financial Instruments Trading Act
. This information was provided to the media for publication at
8:30 a.m. CEST on Sep 28, 2015.

Final results from Active Biotech’s 10TASQ10 Phase 3


This announcement is distributed by NASDAQ OMX Corporate Solutions on behalf of NASDAQ OMX Corporate Solutions clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Active Biotech via Globenewswire


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