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ISR Holdings AB, enters important collaboration regarding Hepatitis B with Beijing Kawin Technology Share-Holding Co., Ltd.

Together with KAWIN, ISR will initiate pre-clinical testing in animal models of HBV evaluating the immunostimulatory properties of ISR50. KAWIN has received a Right of First Refusal (ROFR), which stipulates that KAWIN has the license for the Chinese (PRC) market since KAWIN is financing all the studies. The objective is to explore, negotiate and agree on the detailed and definite terms of the potential license agreement by the 31[st] of May 2021

"Inspired by the successful targeting of Hepatitis C (HCV), we are now joining forces with KAWIN to fight HBV with our immunostimulatory compound ISR50. KAWIN has great expertise in investigating and developing anti-viral drugs, which will be important for a successful collaboration, complementing ISR's expertise in immunology. The two companies make a good logical fit to join efforts to bring a new therapy to the market", comments Ola Winqvist, CEO ISR.

According to WHO, approximately 240 million people globally are chronic carriers of the disease and more than 700 000 HBV infected persons die yearly from the consequences of the disease, liver cirrhosis and liver cancer. Vaccination against HBV has been successful but today there is no existing cure for the already infected.

"We are thrilled to cooperate with ISR that lies in the forefront of immunotherapy to work on curative solutions of hepatitis B in China, especially as the two companies complement each other in anti-viral area. Approximately 70 million people are infected with HBV in China", comments Antonio Cai, BD HEAD of KAWIN.

Chronic virus infections cause a state of immunosuppression, a suppression that can be reversed by stimulating specific antigen presenting cells, i.e. Kupfer cells of the liver, to activate an immune response. ISR 50 is already in late stage toxicology testing where optimal formulation for HBV is developed.

For further information, please contact:
Ola Winqvist
CEO, ISR Immune System Regulation Holding AB (publ) E-post:
Phone: +46 (0)70 5427939

Ticker: ISR
ISIN-kod: SE0008212195 

About KAWIN Beijing Kawin Technology Share-Holding Co., Ltd.Kawin is a leading-edge Chinese pharmaceutical company providing treatment solutions with the focus on viral diseases. Based upon their extensive expertise in drug discovery, drug development, manufacturing, and commercialization in the target area, Kawin recently launched an oral therapy that can achieve cured of HCV infection in China. Kawin owns 7 GMP production lines, working with both biological- and chemical products, and has a turnover of approximately EUR 100 million.

This information is information that ISR Immune System Regulation AB is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 14.43 CET on September 9, 2020.

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