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2022-05-25

Galapagos to showcase commitment to rheumatoid arthritis care at the upcoming European League Against Rheumatism congress

Celebrating EULAR’s 75th anniversary with focus on a new era of rheumatoid arthritis care

Mechelen, Belgium; 25 May 2022, 22.01 CET; Galapagos NV (Euronext & Nasdaq: GLPG) will present 11 abstracts at the European League Against Rheumatism (EULAR) congress 2022, 01-04 June, taking place in Copenhagen, Denmark. The broad range of abstracts include trial data analyses supporting the efficacy and safety profile of filgotinib and real-world clinical data around alignment of prescribing between physicians and rheumatoid arthritis (RA) patients.

Galapagos is also hosting a hybrid symposium: Evolving patient care in RA: Can JAK inhibitors meet patient and physician expectations for RA treatment?”, which will include a discussion focused on aligning physician and patient treatment goals, looking at what is meant by ‘comprehensive care’ and how to ensure that people living with RA are part of treatment and care goal setting. A meet-the-expert session, “Patient-centred care in RA: cutting through the jargon” will feature insights and answers to audience questions on putting patients at the heart of their RA care. Topics will be based on the new era in RA care, with the availability of JAK inhibitors along with a growing body of evidence providing a better understanding of the impact of pain and fatigue, as well as physical symptoms.

A number of abstracts will present trial data analyses on filgotinib, a once-daily oral preferential JAK-1 inhibitor, for the treatment of moderate to severe active RA. These include long-term efficacy and safety data, new analyses on the safety and efficacy of filgotinib in RA patients over the age of 75, and the effect of filgotinib on BMI and body weight. Additionally, Galapagos will present preclinical data on selective SIK3 (salt-inducible kinase) inhibition as a novel mode of action for the treatment of RA.

“The presentations capture our broad range of research and commitment to the RA community, demonstrating the importance of patient and clinical insights and highlighting our position as a science-driven company focusing on patient unmet needs,” said Walid Abi-Saab, MD, Chief Medical Officer at Galapagos. “We know that people living with RA continue to face daily challenges and we learn from their real experiences to inform our medicine development.”

Title Authors Time and Date
Safety of filgotinib in patients with rheumatoid arthritis: Analysis of lymphocytes in the long-term extension FINCH 4 study Jacques Eric Gottenberg, Gerd Burmester, Katrien Van Beneden, Chris Watson, Ineke Seghers, Vijay Rajendran, Lorenzo Dagna, Maya H Buch On-site & virtual display
Poster Number: POS0513
Date: Wednesday, 1 June 08:00 CEST – Sunday 31 July 2022 23:59 CEST (virtual display; onsite display timings TBC)

 
Effect of filgotinib (FIL) on body weight (BW) and body mass index (BMI) and effect of baseline BMI on the efficacy and safety of FIL in rheumatoid arthritis (RA) Alejandro Balsa, Siegfried Wassenberg, Anne Tournadre, Hans-Dieter Orzechowski, Katrien Van Beneden, Vijay Rajendran, Udo Lendl, Pieter-Jan Stiers, Chris Watson, Roberto Caporali, Patrick Verschueren On-site & virtual display
Poster Number: POS0518
Date: Wednesday, 1 June 08:00 CEST – Sunday 31 July 2022 23:59 CEST (virtual display; onsite display timings TBC)
Efficacy and safety of filgotinib in patients aged ≥75 years: a post hoc subgroup analysis of the FINCH 4 long-term extension (LTE) study Daniel Aletaha, René Westhovens, Bernard G Combe, Jacques-Eric Gottenberg, Maya H Buch, Roberto Caporali, Jose A Gómez-Puerta, Paul van Hoek, Vijay Rajendran, Pieter-Jan Stiers, Thijs Hendrikx, Gerd R Burmester, Yoshiya Tanaka On-site & virtual display
Poster Number: POS0676
Date: Wednesday, 1 June 08:00 CEST – Sunday 31 July 2022 23:59 CEST (virtual display; onsite display timings TBC)
The use of exposure-adjusted event rates versus exposure-adjusted incidence rates in adverse event reporting: insights from filgotinib integrated safety data in rheumatoid arthritis Patrick Durez, Eugen Feist, Ricardo Blanco, Vijay Rajendran, Nadia Verbruggen, Katrien Van Beneden, James Galloway On-site & virtual display
Poster Number: POS0663
Date: Wednesday, 1 June 08:00 CEST – Sunday 31 July 2022 23:59 CEST (virtual display; onsite display timings TBC)
Physicians’ reasons for prescribing Janus kinase inhibitors (JAKi) in patients with rheumatoid arthritis (RA), and associated alignment between physicians and patients in a real-world clinical setting Peter C Taylor, Bruno Fautrel, Yves Piette, Susana Romero Yuste, Jasper Broen, Martin Welcker, Elizabeth Holdsworth, Monia Zignani, Katrien Van Beneden, Roberto Caporali, Rieke Alten On-site & virtual display
Poster Number: POS0680
Date: Wednesday, 1 June 08:00 CEST – Sunday 31 July 2022 23:59 CEST (virtual display; onsite display timings TBC)

 
Clinical outcomes up to Week 48 of ongoing filgotinib (FIL) rheumatoid arthritis (RA) long-term extension (LTE) trial of biologic disease-modifying antirheumatic drug (bDMARD) inadequate responders (IR) initially on FIL or placebo in a Phase 3 parent study (PS) Maya H. Buch, Tsutomu Takeuchi, Vijay Rajendran, JE Gottenberg, Alena Pechonkina, YingMeei Tan, Qi Gong, Katrien Van Beneden, Roberto Caporali Abstract publication
Abstract number: AB0394

 
Integrated safety analysis update for filgotinib (FIL) in patients (pts) with moderately to severely active rheumatoid arthritis (RA) receiving treatment over a median of 2.2 years (y) Kevin Winthrop, Yoshiya Tanaka, Tsutomu Takeuchi, Alan J Kivitz, Mark C Genovese, Alena Pechonkina, Franziska Matzkies, Beatrix Bartok, Kun Chen, Deyuan Jiang, Iyabode Tiamiyu, Robin Besuyen, Sander Strengholt, Gerd R Burmester, Jacques-Eric Gottenberg Poster tour presentation, on-site & virtual display
Poster Number: POS0235
Date: 3 June 2022, 12:10:00-12:18:00 CEST (poster tour)
Session: “Rheumatoid arthritis: JAKi and beyond”
Clinical outcomes of methotrexate (MTX)-naïve rheumatoid arthritis (RA) patients (pts) on filgotinib (F...
Författare GlobeNewswire