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Adaptimmune Announces Initiation of Myxoid/Round Cell Liposarcoma Study

n of Myxoid/Round Cell Liposarcoma Study

PHILADELPHIA and OXFORD, United Kingdom, 2016-12-05 13:30 CET (GLOBE NEWSWIRE)
Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in T-cell therapy to treat
cancer, today announced that it has initiated a study of its NY?ESO SPEAR™
T?cells in myxoid/round cell liposarcoma (MRCLS). Patient screening is
underway, and the results from this study in up to 15 patients will inform a
potential future registration trial. The initiation of screening in this study
meets a milestone set forth in the Company’s strategic collaboration agreement
with GlaxoSmithKline plc (LSE/NYSE: GSK).

This is an open-label pilot study in patients to assess preliminary safety and
efficacy in this new indication. Initially, 10 patients will be enrolled. If
further characterization of the treatment is required, up to 5 additional
patients may be enrolled. Eligible patients will be HLA-A*02:01, HLA?A*02:05
and/or HLA-A*02:06 with advanced (metastatic or inoperable) high grade MRCLS
whose tumor shows positive NY-ESO-1 expression defined as ?30 percent of cells
that are 2+ or 3+ by immunohistochemistry. Patients will receive
preconditioning with fludarabine and cyclophosphamide at the same dose that is
being used in Cohort 4 of the Company’s ongoing synovial sarcoma study.

Soft tissue sarcomas can develop from tissues like fat, muscle, nerves, fibrous
tissues, blood vessels, or deep skin tissues. There are approximately 50 types
of soft tissue sarcomas, including MRCLS. Myxoid/round cell liposarcoma is
associated with specific chromosomal translocations and represents about 30 to
35 percent of liposarcomas and 5 to 10 percent of all adult soft tissue
sarcomas. Myxoid/round cell liposarcoma commonly presents at an age ranging
from 35 to 55 years.

About Adaptimmune
Adaptimmune is a clinical stage biopharmaceutical company focused on novel
cancer immunotherapy products based on its SPEAR (Specific Peptide Enhanced
Affinity Receptor) T-cell platform. Established in 2008, the Company aims to
utilize the body’s own machinery - the T-cell - to target and destroy cancer
cells by using engineered, increased affinity TCRs as a means of strengthening
natural patient T-cell responses. Adaptimmune’s lead program is a SPEAR T-cell
therapy targeting the NY-ESO cancer antigen. Its NY-ESO SPEAR T-cell therapy
has demonstrated signs of efficacy and tolerability in Phase 1/2 trials in
solid tumors and in hematologic cancer types, including synovial sarcoma and
multiple myeloma. Adaptimmune has a strategic collaboration and licensing
agreement with GlaxoSmithKline for the development and commercialization of the
NY-ESO TCR program. In addition, Adaptimmune has a number of proprietary
programs. These include SPEAR T-cell therapies targeting the MAGE-A10 and AFP
cancer antigens, which both have open INDs, and a further SPEAR T-cell therapy
targeting the MAGE-A4 cancer antigen that is in pre-clinical phase with IND
acceptance targeted for 2017. The Company has identified over 25 intracellular
target peptides preferentially expressed in cancer cells and is currently
progressing 12 through unpartnered research programs. Adaptimmune has over 250
employees and is located in Oxfordshire, U.K. and Philadelphia, USA. For more

Forward-Looking Statements
This release contains “forward-looking statements” within the meaning of the
Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking
statements involve certain risks and uncertainties. Such risks and
uncertainties could cause our actual results to differ materially from those
indicated by such forward-looking statements, and include, without limitation:
the success, cost and timing of our product development activities and clinical
trials and our ability to successfully advance our TCR therapeutic candidates
through the regulatory and commercialization processes. For a further
description of the risks and uncertainties that could cause our actual results
to differ materially from those expressed in these forward-looking statements,
as well as risks relating to our business in general, we refer you to our
Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission
(SEC) on November 10, 2016, and our other SEC filings. The forward-looking
statements contained in this press release speak only as of the date the
statements were made and we do not undertake any obligation to update such
forward-looking statements to reflect subsequent events or circumstances.

Adaptimmune Contacts

Investor Relations
Will Roberts
T: (215) 825-9306

Juli P. Miller, Ph.D.
T: (215) 825-9310

Media Relations
Margaret Henry
T: +44 (0)1235 430036
Mobile: +44 (0)7710 304249

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